Neurodegenerative diseases are the disorders that causes complete disabilities or death by damaging the neuron cells and affecting the motor and cognitive function of the brain. Alzheimer’s is one such disease which is a type of dementia characterized by memory loss, neuronal death, cognitive decline that ultimately leads to patient’s death. Polymeric nanoparticles are sub-micron sized, solid colloidal particles synthesized from naturalor synthetic polymers. The drug is either loaded inside or conjugated on the surface. As the usage of most of the drugs in treatment of Alzheimer’s is restricted, nanoparticles having smaller size and larger surface area are preferred. Ideal properties of polymeric nanoparticles for drug delivery to the brain is discussed. Special mentions are given about the recent trends and applications of nanoparticles. Further conclusive work needs to be done in treatment of Alzheimer’s disease using polymeric nanoparticles as it makes its way into the mainstream clinical practice.

Children are the any future nation and the major consumers of health care. The study aimed to determine the effectiveness of child to mother approach on knowledge regarding environmental health among mothers of school going children. Quasi experimental non equivalent control group pre-test post-test design and non probability convenience sampling technique was used to select 30 mothers of school going children inexperimental and30 mothers of school going children in control group. A structured self administered knowledge questionnaire was used to assess the knowledge in mothers of school going children about environmental health. The mean difference between pretest  and post test score was 19.36 which was statistically significant at p<0.01 level and found that the child to mother approach was effective in imparting knowledge regarding environmental health among mothers of school going children.

The study describes the safety behaviors and health status of patients with hypertensive cardiovascular disease. A descriptive correlational design was used involving 40 patients recruited through convenience sampling. Mean scores, Chi-square and Pearson-r statistical tests were applied for analysis. Most of the patients belonged to 46-65 years old, females, and married. Duration of illness is about 3 years. The respondent's mean average scores for safety behaviors are generally good (M=2.95). The health status showed that general health is relatively good (2.81±0.97) and limitation of activities ranges from limited to not limited at all. Their physical health or emotional problems slightly interferes social activities. The profile is not significant to the safety behaviors and health status of the respondents. There is no significant correlation between respondent's safety behaviors and health status (r=.159). Provision of optimum care that best suits patient's need must be initiated by the health care providers.

This study aimed to assess the extent of knowledge and compliance to infection control policies of nurses in a private tertiary care hospital. Data were collected using a pretested, researcher-made questionnaire. Chi-square and Pearson-r was used to identify associated factors. T-test was used to determine the difference between knowledge and compliance to infection control policies. The extent of knowledge among nurses is very good and compliance to infection control is very high. Age (χ2=1.655, p=.038) is associated to the extent of knowledge and area of assignment is significant to the extent of knowledge (χ2=70.572, p=.029) and compliance to infection control policies (χ2=94.989, p=.059).There is a relationship between the knowledge and compliance to infection control policies (r=.361, p=.019). The knowledge (t=53.313, p=.000) and compliance (t=53.255, p=.000) of nurses significantly differs according to area of assignment. More training and educational programs are needed to update knowledge and compliance to infection control.

This review work is a compilation of information from previous publications on analytical techniques for tigecycline, either alone or in combination with other medications. Numerous spectroscopic techniques, such as derivative and chromogenic techniques, were employed. It is also possible to use newly created and improved chromatographic techniques with pharmaceutical formulations and biological fluids. A few LC-MS/MS and HPTLC techniques are also available in addition to these two techniques. The quality by design or design by expert technique is now used in the world of analytical research to obtain an improved method for method validation. This succinct review article can help an analyst decide which approach is best for developing and validating the best analytical method.