In this present study we have analysed the serum parameters such as glucose, cholesterol, urea, uric acid, total protein and albumin along with body mass index (BMI) and blood pressure (BP) in type 2 diabetes mellitus patients who were on treatment and compared these parameters with control group. We also examined the correlation of uric acid with other parameters in diabetes mellitus patients on treatment. The study group comprised of 100 type 2 diabetic subjects and twenty five sex and age matched non-diabetic subjects without family history of diabetics were selected as control. After overnight fasting blood was taken from all the subjects for investigation. The serum of each subject was analysed for the following parameter of serum glucose, serum cholesterol, serum protein, serum albumin, serum uric acid and serum urea. Midstream urine sample was collected in a clean bottle without any preservatives. Urine sample was analysed for urine sugar, urine albumin and urine ketone bodies. All biochemical estimations were done in MISPHA excel chemistry analyser. Statistical data was analysed by SPPSS version 17, ANOVA was used to compare different parameters of study and control groups. Linear regression analysis (Pearson correlation coefficient) was performed for determining the degree of association between different parameters. Body mass index of diabetic patients were compared with control group. A statistically significant difference was found between diabetic and control group with p value<0.001. A statistically significant difference was found between diabetic and control groups in the case of blood pressure. There is statistically significant difference in all the above biochemical parameters between diabetic and control subjects except in serum protein and albumin. In the present study we have compared different parameters of Type II DM patients on drug treatment with control group and we found that BP, BMI, serum glucose, serum cholesterol and uric acid levels of diabetic patients were significantly higher when compared with the control group. Serum urea levels of patients were found to be significantly lower than that of the control group. Serum uric acid levels were found to be inversely correlated with serum glucose levels. Serum uric acid levels were found to be directly correlated with BP and BMI.